Pole-sitter Ryan Blaney was second, followed by Regan Smith, Chase Elliott and Elliott Sadler in the first stand-alone event of the season.
Hornish, in the No. 54 car usually driven by Kyle Busch, led 167 of 250 laps to win in second Nationwide start of the season for Joe Gibbs Racing.
Elliott has a two-point lead over Sadler and Smith in the series points standings.
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